Best Cruises to Italy From the USA

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Embark on a Transatlantic Journey to the Mediterranean

Set sail across the mighty Atlantic and beyond on these fabulous cruises to Italy from the USA. Enjoy the luxury of eight or nine full days at sea, depending on your itinerary, as you head from Fort Lauderdale to ports in Italy, mainland Spain, Portugal, France, and the Canary Islands.

Embark in Ft. Lauderdale, Florida, one of the country’s top beach vacation destinations, with plenty to do and see before you leave. Your cruise will either stop at the Canary Islands, the Azores, or Madeira after a blissful week at sea, before heading through the Strait of Gibraltar, along the coastlines of the Mediterranean and ending in Civitavecchia, the port of Rome. On these cruises to Italy from the USA, you can enjoy sunshine, fine food, and culture in dynamic Spanish cities or the glamorous resorts of the French Riviera, marvel at mighty whales in the Azores, hike around volcanic rock formations in the Canaries, and tour a vineyard in Florence, all in one trip.

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Featured Ports

Florence (La Spezia), Italy

The region of Tuscany is known for its rich landscape, history, and cultural influence on Italy since the Renaissance. In La Spezia, visit the Technical Naval Museum to learn about Italy’s maritime history. Tour the vertiginous coastline of the colorful Cinque Terre by car or boat, or head to see the Leaning Tower of Pisa, both just a short journey away. In Florence, you’ll find an abundance of exquisite, Renaissance-era architecture that frames this endlessly beautiful city. Gaze at priceless art in the Uffizi, visit the magnificent cathedral and shop for fine Italian leather. Then dine at one of the many local osterias in bohemian Santo Spirito, one of the most popular places to chat with friends over a glass of Chianti.

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Rome, Italy

Known as the “Eternal City”, Rome is an iconic destination layered with history, culture, art, and architecture at every angle. Enjoy Italian luxury brand shopping on Via del Corso before heading to Trastevere for a relaxing glass of grappa and a tour of the Baroque-era Palazzo San Callisto. Take a guided tour of the Vatican Museums, where you’ll find priceless collections from Da Vinci, Caravaggio, Raphael, Michaelangelo, and more. Finish your stay with a stroll through the Villa Borghese, where you can walk through manicured gardens and visit the Temple of Esculapio and take a romantic paddle boat ride around the adjacent lake.

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Departure Ports

Fort Lauderdale

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Galapagos Expedition Series

Cruises to Italy From the USA