Porto (Leixoes), Portugal

At the mouth of the Rio Douro lies the city of Porto, known mostly for its port wine trade. With origins dating back to the 5th century, there is plenty to see in this town that was named European Capital of Culture in 2001. Stroll the Ribeira neighborhood along the river, explore the Cathedral area, or tour the port lodges of Vila Nova de Gaia across the river. Savoring a taste of tawny port, tripe and seafood while here is highly recommended.